IDENTIFICAÇÃO DE FORMAS DE AUMENTAR A RENDA PRIVADA DA DIREÇÃO GERAL DE EDUCAÇÃO DE NORTH KHORASAN

This study aimed to identify ways to increase the private income of North Khorasan education. The study was a combination of exploratory design projects in two qualitative and quantitative stages. Due to the quality of the study, the snowball sampling method was used and a total of 22 experts were interviewed. In the quantitative research section, statistical samples were selected from among managers and deputies of the General Administration and financial sector experts in a comprehensive manner. Data analysis and qualitative analysis in the qualitative stage was done by the Foundation's data analysis method and through open coding, central coding, and selective coding, and in a small part, Friedman's test method was used to evaluate and prioritize strategies. Based on the research findings, it was found that privatization and transfer, commercialization, internal resource management, external participation, manpower, and legal-structural measures were among the strategies to increase specific revenues. Also among the specific revenue-generating strategies for training and education were human resource strategies, internal resource management, privatization, and assignment. As a result, officials are encouraged to take effective steps to increase their revenues by properly planning to strengthen and revitalize previous resources and policy and develop new guidelines for using new resources.Este estudo teve como objetivo identificar maneiras de aumentar a renda privada da educação North Khorasan. O estudo foi uma combinação de projetos de design exploratório em duas etapas qualitativas e quantitativas. Devido à qualidade do estudo, o método de amostragem bola de neve foi utilizado e um total de 22 especialistas foram entrevistados. Na seção de pesquisa quantitativa, as amostras estatísticas foram selecionadas entre gerentes e deputados da Administração Geral e especialistas do setor financeiro de forma abrangente. A análise dos dados e a análise qualitativa na etapa qualitativa foram feitas pelo método de análise de dados da Fundação e por meio de codificação aberta, codificação central e codificação seletiva e, em uma pequena parte, o método de teste de Friedman foi utilizado para avaliar e priorizar estratégias. Com base nos resultados da pesquisa, constatou-se que privatização e transferência, comercialização, gestão de recursos internos, participação externa, mão de obra e medidas jurídico-estruturais estavam entre as estratégias para aumentar receitas específicas. Também entre as estratégias específicas de geração de receita para treinamento e educação estavam as estratégias de recursos humanos, gestão de recursos internos, privatização e designação. Como resultado, os funcionários são incentivados a tomar medidas eficazes para aumentar suas receitas, planejando adequadamente para fortalecer e revitalizar os recursos e políticas anteriores e desenvolver novas diretrizes para o uso de novos recursos

Error estimate and adaptive refinement in mixed discrete least squares meshless method

The node moving and multistage node enrichment adaptive refinement procedures are extended in mixed discrete least squares meshless (MDLSM) method for efficient analysis of elasticity problems. In the formulation of MDLSM method, mixed formulation is accepted to avoid second-order differentiation of shape functions and to obtain displacements and stresses simultaneously. In the refinement procedures, a robust error estimator based on the value of the least square residuals functional of the governing differential equations and its boundaries at nodal points is used which is inherently available from the MDLSM formulation and can efficiently identify the zones with higher numerical errors. The results are compared with the refinement procedures in the irreducible formulation of discrete least squares meshless (DLSM) method and show the accuracy and efficiency of the proposed procedures. Also, the comparison of the error norms and convergence rate show the fidelity of the proposed adaptive refinement procedures in the MDLSM method

Internal Medicine Residency Newsletter, April 2023

A newsletter created by and for the Rochester General Hospital Internal Medicine Residency Program. This issue: A word from the PD News & announcements Resident corner Awards and scholarship Conferences and deadlines Introducing IMRC Article of the month Community outreach activities Happy birthday! Crossword puzzl

Evaluation of a nanodispersion formulation prepared through microfluidic reactors for pulmonary delivery of budesonide using nebulizers

This study aimed to determine the aerosolization behavior of a nanodispersion of budesonide, prepared using microfluidic reactors. The size and morphology of budesonide nanoparticles were characterized by photon correlation spectroscopy (PCS) and transmission electron microscopy (TEM). Processing/formulation parameters for formation of the nanoparticles were studied to determine their effects on the particle size. Results showed a narrow distribution for budesonide nanodispersion with spherical and smooth surfaced particles. To investigate the in-vitro aerosolization performance of the nanodispersion, the preparation was compared with a commercially available budesonide microsuspension using the Comité Européen Normalization (CEN) methodology. Aerosolization results showed that the fine particle fraction (FPF) generated from the budesonide nanodispersion was significantly higher than that of the marketed budesonide (ie. mean (SD) 56.88 (3.37) vs. 38.04 (7.82), respectively). Additionally, mass median aerodynamic diameter (MMAD) of nano-budesonide dispersion was significantly smaller than the microsuspension (ie. mean (SD) 3.91 (0.49) vs. 6.22 (1.09) μm, respectively), with nebulization time of nano-budesonide dispersion significantly shorter than the marketed budesonide microsuspension (ie. 12.3 (0.37) vs. 14.85 (0.36) min, respectively). The produced nanodispersion was found to be stable over a period of 10 days if stored at 4 °C. © 2014 by School of Pharmacy Shaheed Beheshti University of Medical Sciences and Health Services

The effect of ingredients’ concentration on nanoemulsion particle size of eucalyptus essential oil

This study aimed to determine the effect of different parameters affecting the particle size of eucalyptus-essential oil nanoemulsion using artificial neural networks. The formulation of nanomaterials used in this study included Tween 80 (as surfactant), ethanol (as co-surfactant), and eucalyptus essential oil (as internal phase), in water. To prepare the nanoemulsion, the mixtures were sonicated and the size of resulting nanoparticles were measured using dynamic light scattering (DLS). Then, the data were modelled using artificial neural networks. The results revealed that high Tween 80 concentration and low essential oil concentration had positive effects on reduction of particle size, while the change in ethanol concentration had no obvious impact on the size. The prepared nanoemulsions has the potential to be used in biomedical applications

Effect of Processing/Formulation Parameters on Particle Size of Nanoemulsions Containing Ibuprofen - An Artificial Neural Networks Study

Background: Nanoemulsions are colloidal transparent systems for the delivery of hydrophobic drugs. This study aimed to determine the effect of parameters affecting particle size of a nanoemulsion containing ibuprofen using artificial neural networks (ANNs). Methods: Nanoemulsion samples with different values of independent variables, namely, concentration of ethanol, ibuprofen and Tween 80 as well as exposure (homogenization) time were prepared and their particle size was measured using dynamic light scattering (DLS). The data were then modelled by ANNs. Results: From the results, increasing the exposure time had a positive effect on reducing droplet size. The effect of concentration of ethanol and Tween 80 on droplet size depended on the amount of ibuprofen. Our results demonstrate that ibuprofen concentration also had a reverse relation with the size of the nanoemulsions. Conclusion: It was concluded that to obtain minimum particle size, exposure (homogenization)time should be maximized

Effect of Material and Population on the Delivery of Nanoparticles to an Atherosclerotic Plaque : A Patient-specific In Silico Study

acceptedVersionPeer reviewe

Evaluation of Presence of Candida in Complete Denture Wearer in Tissue and Denture Surfaces Using Smear Method

Background: Candidiasis is the most frequent fungal infection of the human oral cavity. Candida albicans is an opportunistic fungal microorganism and normal flora of the oral cavity. While different Candida species can cause infection, 85% of all oral cavity fungal infections are caused by Candida albicans; other types can cause infection less frequently. Aim: This study aims to determine Candida count as an index of fungal contamination in dentures. The results would determine the level of patients’ oral hygiene and can be useful in infection control programs which consequently would assist in the prevention of opportunistic fungal infections, particularly, in elderly people. Methods: In this experimental study, 100 patients with complete denture randomly selected from the city of Ardabil. Before completing the study questionnaires, consent of patient taken by orally and the necessary demographic data were collected to all patients. Samples were collected two times with two-month interval. The samples were stained with Giemsa using the direct smear method and were studied under light microscope. Data were analyzed by statistical methods such as table and graph and Chi-Square test using SPSS.16 software. Results: Out of 100 studied individuals, 53 had Candida (with different frequency), which was directly associated with cigarette smoking (duration of usage and the number of cigarettes used), and also the oral hygiene maintenance. Conclusion: Oral hygiene maintenance, patient’s training, ceasing the smoking habit and controlling systematic diseases can decrease the amount of Candida in the oral cavity

Subchronic effects of different doses of Zinc oxide nanoparticle on reproductive organs of female rats: An experimental study

Background: Zinc performs many biochemical and physiological functions; however, toxicological studies demonstrate that Nano-zinc oxide has harmful effects on human health and environmental species in high concentrations. Objective: The aim of this study was to investigate the toxicity of zinc oxide nanoparticles on reproductive tissues of female rat. Materials and Methods: Eighty female Wistar adult rats weighing 180–200 gr, divided into eight groups (n= 10 in each group) including control, sham (treated with saline), and six groups injected with different doses of zinc oxide nanoparticle with 10–30 nanometer size (4, 8, 25, 50, 100, and 200 mg/kg) twice a week for four weeks. At the end of the study, the rats were bled and slaughtered; the Ovary and Uterus were taken for histopathology studies and blood samples were transferred to the laboratory for biochemical analysis. Results: Microscopic diagnoses in ovary tissue were included; increase in the corpus luteum, follicular cysts, inflammatory cells infiltration and fibrosis. Histopathological changes in ovary in a dose-dependent manner. In uterus tissue the lesions consisted; epithelial destruction, hyperplasia of endometrial glands. The Estrogen and Progesterone level in the serum of rats increased in low doses and reduced in a dose-dependent manner at high doses. Conclusion: The results of the current study proved the toxicity of zinc oxide nanoparticles on the ovary and uterus organs at high concentrations, so further investigation is needed to reduce these effects. Key words: Zinc oxide, Nanoparticles, Ovary, Uterus, Toxicity